Synthesis of α-fluorosulfonamides by electrophilic fluorination

被引：43

作者：

Hill, B ^{[1
]}

Yong, L ^{[1
]}

Taylor, SD ^{[1
]}

机构：

[1] Univ Waterloo, Dept Chem, Waterloo, ON N2L 3G1, Canada

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 23期

关键词：

D O I：

10.1021/ol048249z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Fluorosulfonamides were prepared by electrophilic fluorination of tertiary sulfonamides using N-fluorobenzenesulfonimide as fluorinating agent and utilizing the dimethoxybenzyl group (DMB) as a new sulfonamide protecting group. Removal of the DMB group with TFA/CH2Cl2 gave primary and secondary alpha-fluorosulfonamides.

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页码：4285 / 4288

页数：4

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