Association between chronic disseminated candidiasis in adult acute leukemia and common IL4 promoter haplotypes

被引：39

作者：

Choi, EH

Foster, CB

Taylor, JG

Erichsen, HC

Chen, RA

Walsh, TJ

Anttila, VJ

Ruutu, T

Palotie, A

Chanock, SJ

机构：

[1] NCI, Sect Genom Variat, Pediat Oncol Branch, Ctr Adv Technol,NIH, Gaithersburg, MD 20892 USA

[2] NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA

[3] Univ Helsinki, Cent Hosp, Dept Med, Div Hematol, Helsinki, Finland

[4] Univ Helsinki, Cent Hosp, Dept Med, Div Infect Dis, Helsinki, Finland

[5] Univ Helsinki, Cent Hosp, Dept Clin Chem, Helsinki, Finland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2003年 / 187卷 / 07期

关键词：

D O I：

10.1086/368345

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic disseminated candidiasis (CDC) is a form of Candida species infection observed primarily in patients with acute leukemia. To investigate possible genetic factors associated with CDC, we conducted a pilot study of 40 patients with both leukemia and CDC and 50 control patients with leukemia only. A common haplotype of the IL4 promoter (-1098T/-589C/ -33C) was overrepresented in patients with CDC (P = .01; odds ratio [OR], 2.16), whereas another common haplotype (-1098T/-589T/ -33T) appeared to be protective against CDC (P = .018; OR, 0.47). Genetic variants of IL4 could contribute to the development of CDC in patients with acute leukemia.

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页码：1153 / 1156

页数：4

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