Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease

被引:24
作者
Akobeng, Anthony K. [1 ]
Richmond, Kathryn
Miller, Victor
Thomas, Adrian G.
机构
[1] Cent Manchester & Manchester Childrens Univ Hosp, Booth Hall Childrens Hosp, Dept Paediat Gastroenterol, Manchester, Lancs, England
[2] Cent Manchester & Manchester Childrens Univ Hosp, Booth Hall Childrens Hosp, Dept Biochem, Manchester, Lancs, England
关键词
Crohn's disease; inflammatory bowel disease; antioxidants; enteral nutrition; glutamine;
D O I
10.1016/j.clnu.2006.10.004
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background Et Aims: Oxidative stress and depletion of antioxidants may play a role in the pathogenesis of Crohn's disease (CD). The aim of this study was to determine the effect of exclusive enteral nutrition, which is increasingly being used as primary therapy for CD, on plasma antioxidant concentrations in children with active CD. Methods: In a double-blind randomised controlled trial, 15 children with active CD (mean age, 11.3 years, range 6.8-15.7) attending a paediatric gastroenterology referral centre, were assigned to receive either a standard polymeric diet (Group S, n = 8) or a glutamine-enriched polymeric diet (Group G, n = 7) as primary therapy for active CD. Plasma concentrations of selenium, urates, vitamin A, vitamin E, vitamin C, glutathione, and also malondialdehyde (MDA) were measured at baseline and after 4 weeks of exclusive enteral nutritional treatment. Results: Mean (95% CI) selenium concentration of the cohort increased significantly from 0.82 mu mol/l (0.72, 0.91) to 1.14 mu mol/l (0.98, 1.3), P < 0.001. There were, however, significant reductions in mean concentrations of vitamin C {11.8 mg/l (7.7, 15.8) to 6.5 mg/ l (4.5, 8.7), P=0.01} and vitamin E [11.3 mg/l (10.3, 12.4) to 9.4 mg/l (8.7, 10.1), P = 0.03). The concentrations of vitamin A, urates, glutathione and MDA did not change significantly over the study period. Glutamine supplementation did not have any significant effect on plasma antioxidant concentrations. Conclusions: Significant changes in circulating antioxidant concentrations occurred in children with active CD receiving exclusive enteral nutritional treatment. Glutamine supplementation was not beneficial in improving plasma antioxidant status. (c) 2006 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
引用
收藏
页码:51 / 56
页数:6
相关论文
共 25 条
[1]   Double-blind randomized controlled trial of glutamine-enriched polymeric diet in the treatment of active Crohn's disease [J].
Akobeng, AK ;
Miller, V ;
Stanton, J ;
Elbadri, AM ;
Thomas, AG .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2000, 30 (01) :78-84
[2]   THE SCAVENGING OF OXIDANTS BY SULFASALAZINE AND ITS METABOLITES - A POSSIBLE CONTRIBUTION TO THEIR ANTIINFLAMMATORY EFFECTS [J].
ARUOMA, OI ;
WASIL, M ;
HALLIWELL, B ;
HOEY, BM ;
BUTLER, J .
BIOCHEMICAL PHARMACOLOGY, 1987, 36 (21) :3739-3742
[3]   Enteral. nutrition as primary therapy in childhood Crohn's disease: Control of intestinal inflammation and anabolic response [J].
Beattie, Robert M. .
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 2005, 29 (04) :S151-S159
[4]   DETERMINATION OF MALONALDEHYDE IN BIOLOGICAL-MATERIALS BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY [J].
BIRD, RP ;
HUNG, SSO ;
HADLEY, M ;
DRAPER, HH .
ANALYTICAL BIOCHEMISTRY, 1983, 128 (01) :240-244
[5]   Vitamins A and E serum levels in children and young adults with inflammatory bowel disease: Effect of disease activity [J].
Bousvaros, A ;
Zurakowski, D ;
Duggan, C ;
Law, T ;
Rifai, N ;
Goldberg, NE ;
Leichtner, AM .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1998, 26 (02) :129-135
[6]  
Buege J A, 1978, Methods Enzymol, V52, P302
[7]   Glutamine-enriched total parenteral nutrition enhances plasma glutathione in the resting state [J].
Denno, R ;
Rounds, JD ;
Faris, R ;
Holejko, LB ;
Wilmore, DW .
JOURNAL OF SURGICAL RESEARCH, 1996, 61 (01) :35-38
[8]  
*DEP HLTH, 1991, REP HLTH SOC SUBJ DI, P41
[9]  
FERNANDEZBANARES F, 1989, AM J GASTROENTEROL, V84, P744
[10]   Scarcity in the midst of plenty: Enteral tube feeding complicated by scurvy [J].
Gorman, SR ;
Armstrong, G ;
Allen, KR ;
Ellis, J ;
Puntis, JWL .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2002, 35 (01) :93-95