Long-term arsenic exposure and incidence of non-insulin-dependent diabetes mellitus: A cohort study in arseniasis-hyperendemic villages in Taiwan

被引:270
作者
Tseng, CH
Tai, TY
Chong, CK
Tseng, CP
Lai, MS
Lin, BJ
Chiou, HY
Hsueh, YM
Hsu, KH
Chen, CJ
机构
[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan
[2] Taipei Med Coll, Grad Inst Publ Hlth, Taipei, Taiwan
[3] Chang Gung Mem Hosp, Dept Rehabil, Taipei 10591, Taiwan
[4] Chongs Phys Med & Rehabil Clin, Taipei, Taiwan
[5] Chang Gung Univ, Sch Med Technol, Tao Yuan, Taiwan
[6] Cent Bur Natl Hlth Insurance, Taipei, Taiwan
[7] Chang Gung Univ, Dept Hlth Care Management, Tao Yuan, Taiwan
[8] Natl Taiwan Univ, Coll Publ Hlth, Grad Inst Epidemiol, Taipei 10764, Taiwan
关键词
diabetes mellitus; incidence; ingested arsenic; oral glucose tolerance test; water pollutant;
D O I
10.2307/3434992
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Diabetes prevalence in arseniasis-hyperendemic villages in Taiwan has been reported to be significantly higher than in the general population. The aim of this cohort study was to further evaluate the association between ingested inorganic arsenic and the incidence of non-insulin-dependent diabetes mellitus in these villages. A total of 446 nondiabetic residents in these villages were followed biannually by oral glucose tolerance test. Diabetes is defined as a fasting plasma glucose level greater than or equal to 7.8 mmol/L andlor a 2-hr post-load glucose level greater than or equal to 11.1 mmol/L. During the follow-up period of 1499.5 person-years, 41 cases developed diabetes, showing an overall incidence of 27.4/1,000 person-years. The incidence of diabetes correlated with age, body mass index, and cumulative arsenic exposure. The multivariate-adjusted relative risks were 1.6, 2.3, and 2.1 for age greater than or equal to 55 versus < 55 years, a body mass index greater than or equal to 25 versus < 25 kg/m(2), and a cumulative arsenic exposure greater than or equal to 17 versus < 17 mg/L-years, respectively. The incidence density ratios (95% confidence intervals) between the hyperendemic villages and the two nonendemic control townships were 3.6 (3.5-3.6), 2.3 (1.1-4.9), 4.3 (2.4-7.7), and 5.5 (2.2-13.5), respectively, for the age groups of 35-44, 45-54, 55-64, and 65-74 years. The findings are consistent with our previous cross-sectional observation that ingested inorganic arsenic is diabetogenic in human beings.
引用
收藏
页码:847 / 851
页数:5
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