α,β-Differentiated tandem diamination of cinnamic esters using N,N-dichloro-2-nitrobenzenesulfonamide and acetonitrile as the nitrogen sources

被引:54
作者
Li, GG [1 ]
Kim, SH [1 ]
Wei, HX [1 ]
机构
[1] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA
关键词
diamination; vicinal diamines; nitrobenzenesulfonamide; alpha; beta-diamino acids;
D O I
10.1016/S0040-4039(00)01579-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Tandem diamination of cinnamic esters provides a new approach to anti alkyl N alpha-(2-Ns), N beta -Ac diaminophenylpropionates. The new reaction proceeds to completion within 3 hours at room temperature using N,N-dichloro-2-nitrobenzenesulfonamide (2-NsNCl(2)) as the nitrogen source in acetonitrile, which is also involved in the reaction process. Seven diamine derivatives have been obtained with good yields and stereoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:8699 / 8703
页数:5
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