Generation of the NUP98-TOP1 fusion transcript by the t(11;20) (p15;q11) in a case of acute monocytic leukemia

被引：10

作者：

Chen, SN

Xue, YQ ^{[1
]}

Chen, Z

Guo, Y

Wu, YF

Pan, JL

机构：

[1] Soochow Univ, Affiliated Hosp 1, Leukemia Res Unit, Jiangsu Inst Hematol, Suzhou, Peoples R China

[2] Univ Utah, Cytogenet Lab, Div Med Genet, Salt Lake City, UT USA

来源：

CANCER GENETICS AND CYTOGENETICS | 2003年 / 140卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(02)00642-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A rare chromosomal translocation, (11;20)(p15;q11), was detected in a 29-year-old male patient diagnosed with acute monocytic leukemia (AMoL) according to the French-American-British classification criteria. Whole chromosome painting analysis with paints for chromosomes I I and 20 confirmed the result of conventional cytogenetic analysis. Reverse transcriptase polymerase chain reaction revealed the NUP98-TOP1 fusion transcript. To our knowledge, this is the second report of the translocation involving NUP98 and TOP1 genes in AMoL. On reviewing the literature, we suggest that t(11;20)(p15;q11) is associated with myelocytic disorders rather than lymphocytic proliferative diseases. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：153 / 156

页数：4

共 15 条

[1]

Ahuja HG, 2000, CANCER RES, V60, P6227

[2] The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion [J].