Breaking up is hard to do

被引：37

作者：

Stoddard, BL ^{[1
]}

Pietrokovski, S ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98104 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1998年 / 5卷 / 01期

关键词：

D O I：

10.1038/nsb0198-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the gyrA intein provides a view of its active site prior to the initial step of the protein splicing pathway. An intact leaving group at the N-terminal splice junction displays a highly strained cis geometry that is potentially critical for driving the isomerization of the scissile peptide bond, inducing subsequent cleavage.

引用

页码：3 / 5

页数：3

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