Characterisation of amorphous and nanocrystalline molecular materials by total scattering

被引：66

作者：

Billinge, Simon J. L. ^{[1
,2
]}

Dykhne, Timur ^{[1
]}

Juhas, Pavol ^{[1
]}

Bozin, Emil ^{[1
,2
]}

Taylor, Ryan ^{[3
]}

Florence, Alastair J. ^{[3
]}

Shankland, Kenneth ^{[4
]}

机构：

[1] Columbia Univ, Dept Appl Phys & Appl Math, New York, NY 10027 USA

[2] Brookhaven Natl Lab, Condensed Matter Phys & Mat Sci Dept, Upton, NY 11973 USA

[3] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Solid State Res Grp, Glasgow G4 ONR, Lanark, Scotland

[4] Univ Reading, Sch Pharm, Reading RG6 6AD, Berks, England

来源：

CRYSTENGCOMM | 2010年 / 12卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

INDOMETHACIN; DIFFRACTION; POLYMORPHS;

D O I：

10.1039/b915453a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of high-energy X-ray total scattering coupled with pair distribution function analysis produces unique structural fingerprints from amorphous and nanostructured phases of the pharmaceuticals carbamazepine and indomethacin. The advantages of such facility-based experiments over laboratory-based ones are discussed and the technique is illustrated with the characterisation of a melt-quenched sample of carbamazepine as a nanocrystalline (4.5 nm domain diameter) version of form III.

引用

页码：1366 / 1368

页数：3

共 15 条

[1] Crystal nucleation and growth of indomethacin polymorphs from the amorphous state [J].

Andronis, V ;

Zografi, G .

JOURNAL OF NON-CRYSTALLINE SOLIDS, 2000, 271 (03) :236-248

[2] PolySNAP:: a computer program for analysing high-throughput powder diffraction data [J].

Barr, G ;

Dong, W ;

Gilmore, CJ .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 2004, 37 :658-664

[3] Analysis of amorphous and nanocrystalline solids from their X-ray diffraction patterns [J].

Bates, Simon ;

Zografi, George ;

Engers, David ;

Morris, Kenneth ;

Crowley, Kieran ;

Newman, Ann .

PHARMACEUTICAL RESEARCH, 2006, 23 (10) :2333-2349

[4] Nanoscale structural order from the atomic pair distribution function (PDF): There's plenty of room in the middle [J].

Billinge, Simon J. L. .

JOURNAL OF SOLID STATE CHEMISTRY, 2008, 181 (07) :1695-1700

[5] The problem with determining atomic structure at the nanoscale [J].

Billinge, Simon J. L. ;

Levin, Igor .

SCIENCE, 2007, 316 (5824) :561-565

[6]

BORKA L, 1974, ACTA PHARM SUEC, V11, P295

[7] Reactivity differences of indomethacin solid forms with ammonia gas [J].

Chen, XM ;

Morris, KR ;

Griesser, UJ ;

Byrn, SR ;

Stowell, JG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (50) :15012-15019

[8] γ-indomethacin at 120 K [J].

Cox, PJ ;

Manson, PL .

ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2003, 59 :O986-O988

[9]

Egami T, 2003, PERGAMON MATER SER, V7, pVII

[10] Comparison of the four anhydrous polymorphs of carbamazepine and the crystal structure of form I [J].

Grzesiak, AL ;

Lang, MD ;

Kim, K ;

Matzger, AJ .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 92 (11) :2260-2271

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