Role of κ-opioid receptor activation in pharmacological preconditioning of swine

被引:26
作者
Coles, JA
Sigg, DC
Iaizzo, PA
机构
[1] Univ Minnesota, Dept Surg, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Physiol, Minneapolis, MN 55455 USA
[3] Univ Minnesota, Inst Biomed Engn, Minneapolis, MN 55455 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2003年 / 284卷 / 06期
关键词
morphine; norbinaltorphimine; pentazocine;
D O I
10.1152/ajpheart.00843.2002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Pharmacological preconditioning with kappa-opioid receptor agonists is proarrhythmic and exerts antipreconditioning effects in rats. In swine, it is unknown whether kappa-opioid receptor stimulation plays a role in pharmacological preconditioning. Swine were preconditioned with 1) saline (controls), 2) [D-Ala(2),D-Leu(5)] enkephalin (DADLE), 3) morphine, 4) pentazocine, 5) norbinaltorphimine (nor-BNI), 6) DADLE + nor-BNI, 7) morphine + nor-BNI, or 8) pentazocine + nor-BNI before occlusion (45 min) and reperfusion (180 min) of the left anterior descending coronary artery. Infarct size to area at risk (IS), regional (systolic shortening) and global (pressures and flows) myocardial function, and arrhythmia occurrence were assessed. Only DADLE + nor-BNI preconditioning significantly decreased infarct size compared with controls (47 +/- 13 vs. 65 +/- 5%, P < 0.05); morphine preconditioning was not cardioprotective with or without kappa-opioid receptor blockade (nor-BNI). DADLE preconditioning significantly increased ischemia-induced arrhythmias relative to controls, whereas pentazocine-preconditioned animals (n = 2) experienced intractable ventricular fibrillation during ischemia. kappa-Opioid receptor blockade with DADLE or pentazocine preconditioning alleviated proarrhythmic effects. These results suggest that kappa-opioid receptor activation during pharmacological preconditioning is proarrhythmic in swine.
引用
收藏
页码:H2091 / H2099
页数:9
相关论文
共 55 条
[1]   Opposing effects on infarction of delta and kappa opioid receptor activation in the isolated rat heart: implications for ischemic preconditioning [J].
Aitchison, KA ;
Baxter, GF ;
Awan, MM ;
Smith, RM ;
Yellon, DM ;
Opie, LH .
BASIC RESEARCH IN CARDIOLOGY, 2000, 95 (01) :1-10
[2]   Delta opioid receptor stimulation mimics ischemic preconditioning in human heart muscle [J].
Bell, SP ;
Sack, MN ;
Patel, A ;
Opie, LH ;
Yellon, DM .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (07) :2296-2302
[3]   ACUTE CORONARY-ARTERY OCCLUSION-REPERFUSION-INDUCED ARRHYTHMIAS IN RATS, DOGS AND PIGS - ANTIARRHYTHMIC EVALUATION OF QUINIDINE, PROCAINAMIDE AND LIDOCAINE [J].
BERGEY, JL ;
NOCELLA, K ;
MCCALLUM, JD .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1982, 81 (02) :205-216
[4]   ANTI-ARRHYTHMIC EVALUATION OF NALOXONE AGAINST ACUTE CORONARY OCCLUSION-INDUCED ARRHYTHMIAS IN PIGS [J].
BERGEY, JL ;
BEIL, ME .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1983, 90 (04) :427-431
[5]   NORBINALTORPHIMINE - ANTAGONIST PROFILE AT KAPPA-OPIOID RECEPTORS [J].
BIRCH, PJ ;
HAYES, AG ;
SHEEHAN, MJ ;
TYERS, MB .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 144 (03) :405-408
[6]   Opioids confer myocardial tolerance to ischemia: Interaction of delta opioid agonists and antagonists [J].
Bolling, SF ;
Badhwar, V ;
Schwartz, CF ;
Oeltgen, PR ;
Kilgore, K ;
Su, TP .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2001, 122 (03) :476-481
[7]  
CHIEN S, 1994, J THORAC CARDIOV SUR, V107, P964
[8]   Smaller infarct after preconditioning does not predict extent of early functional improvement of reperfused heart [J].
Cohen, MV ;
Yang, XM ;
Downey, JM .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1999, 277 (05) :H1754-H1761
[9]   QUANTIFICATION OF ARRHYTHMIAS USING SCORING SYSTEMS - AN EXAMINATION OF 7 SCORES IN AN INVIVO MODEL OF REGIONAL MYOCARDIAL ISCHEMIA [J].
CURTIS, MJ ;
WALKER, MJA .
CARDIOVASCULAR RESEARCH, 1988, 22 (09) :656-665
[10]   Distinct components of morphine effects on cardiac myocytes are mediated by the kappa and delta opioid receptors [J].
Ela, C ;
Barg, J ;
Vogel, Z ;
Hasin, Y ;
Eilam, Y .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1997, 29 (02) :711-720