Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens

The activity of trovafloxacin and five other oral agents against 250 aerobic and 137 anaerobic strains isolated from human and animal bite wounds was determined by an agar dilution method. Trovafloxacin was active against all aerobic and fastidious facultative isolates at less than or equal to 0.5 mg/L and all anaerobes at less than or equal to 2 mg/L (Bacteroides tectum, Porphyromonas salivosa and Prevotella heparinolytica, less than or equal to 0.25 mg/L; Porphyromonas spp., less than or equal to 0.5 mg/L; Prevotella spp. and peptostreptococci, less than or equal to 2.0 mg/L), except Fusobacterium nucleatum and other fusobacteria (MIC90 less than or equal to 4 mg/L). Levofloxacin was generally one to two dilutions more active than ofloxacin, while ciprofloxacin was active against aerobes (MIC less than or equal to 1 mg/L) but less active against anaerobic strains (MIC90 less than or equal to 16 mg/L).