Gating of store-operated channels by conformational coupling to ryanodine receptors

被引：132

作者：

Kiselyov, KI

Shin, DM

Wang, YM

Pessah, IN

Allen, PD

Muallem, S ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Physiol, Dallas, TX 75235 USA

[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Anesthesia, Boston, MA 02115 USA

[3] Univ Calif Davis, Sch Vet Med, Dept Mol Biophys, Davis, CA 95616 USA

来源：

MOLECULAR CELL | 2000年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(00)00041-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here that RyRs interact with and gate the store-operated hTrp3 and I-crac channels. This gating contributes to activation of hTrpS and I-crac by agonists. Coupling of hTrp3 to IP(3)Rs or RyRs in the same cells was found to be mutually exclusive. Biochemical and functional evidence suggest that mutually exclusive coupling reflects clustering and segregation of hTrp3-RyR and hTrp3-RyR complexes in plasma membrane microdomains. Gating of CCE by RyRs indicates that gating by conformational coupling is not unique to skeletal muscle but is a general mechanism for communication between events in the plasma and endoplasmic reticulum membranes.

引用

页码：421 / 431

页数：11

共 42 条

[1] AIREY JA, 1990, J BIOL CHEM, V265, P14187
[2] The caveolae membrane system
Anderson, RGW
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 : 199 - 225
[3] Deletion of the ryanodine receptor type 3 (RyR3) impairs forms of synaptic plasticity and spatial learning
Balschun, D
Wolfer, DP
Bertocchini, F
Barone, V
Conti, A
Zuschratter, W
Missiaen, L
Lipp, HP
Frey, JU
Sorrentino, V
[J]. EMBO JOURNAL, 1999, 18 (19) : 5264 - 5273
[4] Functional and structural approaches to the study of excitation-contraction coupling
Beam, KG
FranziniArmstrong, C
[J]. METHODS IN CELL BIOLOGY, VOL 52: METHODS IN MUSCLE BIOLOGY, 1997, 52 : 283 - 306
[5] Bennett DL, 1998, BIOCHEM J, V329, P349
[6] CAPACITATIVE CALCIUM-ENTRY
BERRIDGE, MJ
[J]. BIOCHEMICAL JOURNAL, 1995, 312 : 1 - 11
[7] Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles
Bertocchini, F
Ovitt, CE
Conti, A
Barone, V
Schöler, HR
Bottinelli, R
Reggiani, C
Sorrentino, V
[J]. EMBO JOURNAL, 1997, 16 (23) : 6956 - 6963
[8] Modulation of Ca2+ entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP3R) that bind transient receptor potential (TRP):: Evidence for roles of TRP and IP3R in store depletion-activated Ca2+ entry
Boulay, G
Brown, DM
Qin, N
Jiang, MS
Dietrich, A
Zhu, MX
Chen, ZG
Birnbaumer, M
Mikoshiba, K
Birnbaumer, L
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) : 14955 - 14960
[9] Role of the inositol 1,4,5-trisphosphate receptor in Ca2+ feedback inhibition of calcium release-activated calcium current (Icrac)
Broad, LM
Armstrong, DL
Putney, JW
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) : 32881 - 32888
[10] Functional coupling between ryanodine receptors and L-type calcium channels in neurons
Chavis, P
Fagni, L
Lansman, JB
Bockaert, J
[J]. NATURE, 1996, 382 (6593) : 719 - 722

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