Germinal centers: programmed for affinity maturation and antibody diversification

被引：152

作者：

Bannard, Oliver ^{[1
]}

Cyster, Jason G. ^{[2
,3
]}

机构：

[1] Univ Oxford, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England

[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2017年 / 45卷

基金：

英国惠康基金;

关键词：

CENTER B-CELLS; BROAD NEUTRALIZING ANTIBODIES; FOLLICULAR DENDRITIC CELLS; MHC CLASS-II; SPHINGOSINE; 1-PHOSPHATE; CENTER CONFINEMENT; CLONAL SELECTION; IMMUNE-RESPONSE; CENTER DARK; IN-VIVO;

D O I：

10.1016/j.coi.2016.12.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The seminal discovery by Eisen that antibodies undergo improvements in antigen-binding affinity over the course of an immune response led to a long running search for the underlying mechanism. Germinal centers in lymphoid organs are now recognized to be critically involved in this phenomenon, known as antibody affinity maturation. As well as improving in affinity for specific epitopes, some antibody responses maintain or even increase their breadth of antigen-recognition over time. This has led to another intense line of research aimed at understanding how broadly neutralizing anti-pathogen responses are generated. Recent work indicates that germinal centers also play an important role in the diversification process. We discuss current understanding of how germinal centers are programmed to support both affinity maturation and antibody diversification.

引用

页码：21 / 30

页数：10

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