Sonogashira coupling reaction with diminished homocoupling

被引：271

作者：

Elangovan, A ^{[1
]}

Wang, YH ^{[1
]}

Ho, TI ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 11期

关键词：

D O I：

10.1021/ol034320+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The side product from homocoupling reaction of two terminal acetylenes in the Sonogashira reaction can be reduced to about 2% using an atmosphere of hydrogen gas diluted with nitrogen or argon. Terminal arylethynes, diarylethynes, and a few new arylpyridylethynes with donor substituents have been synthesized in very good yields. Comparative control experiments suggest that the homocoupling yield is determined by concentration of both catalyst and oxygen.

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页码：1841 / 1844

页数：4

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