A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum

被引：224

作者：

Ploegh, Hidde L. ^{[1
]}

机构：

[1] MIT, Whitehead Inst Biomed Res, Dept Biol, Cambridge, MA 02142 USA

来源：

NATURE | 2007年 / 448卷 / 7152期

关键词：

D O I：

10.1038/nature06004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lipids are not encoded by a DNA template and therefore cannot be mutated, knocked out or knocked down. This by no means renders them impotent from a cell biological perspective. Here I propose a model for the involvement of lipid rearrangements in the execution of crucial steps in ( glyco) protein quality control.

引用

页码：435 / 438

页数：4

共 45 条

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