Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation

被引：103

作者：

Cheng, IH

Palop, JJ

Esposito, LA

Bien-Ly, N

Yan, FG

Mucke, L ^{[1
]}

机构：

[1] Univ Calif San Francisco, Gladstone Inst Neurol Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94158 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 11期

关键词：

D O I：

10.1038/nm1123

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Arctic mutation within the amyloid-(A) peptide causes Alzheimer disease. In vitro, Arctic-mutant A forms (proto) fibrils more effectively than wild-type A. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). Amyloid plaques formed faster and were more extensive in Arctic mice than in hAPP mice expressing wild-type A, even though Arctic mice had lower Abeta(1-42/1-40) ratios. Thus, the Arctic mutation is highly amyloidogenic in vivo.

引用

页码：1190 / 1192

页数：3

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