Chemical tools for mechanistic studies related to catechol oxidase activity

被引：37

作者：

Belle, Catherine ^{[1
]}

Selmeczi, Katalin ^{[1
]}

Torelli, Stephane ^{[1
]}

Pierre, Jean-Louis ^{[1
]}

机构：

[1] Univ Grenoble 1, CNRS 2607, ICMB FR, CNRS 5616,Equipe Chim Biomimet,LEDDS, F-38041 Grenoble 9, France

来源：

COMPTES RENDUS CHIMIE | 2007年 / 10卷 / 4-5期

关键词：

catechol oxidase; model complexes; catalytic mechanism; F-19; NMR;

D O I：

10.1016/j.crci.2006.10.007

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Important questions remain unanswered concerning the catalytic mechanism of catechol oxidase, an enzyme with a coupled dinuclear copper active site, which catalyzes the oxidation of o-diphenols to o-quinones in presence of dioxygen. In this review we try to demonstrate how well-suited biomimetic models could help elucidate the mechanistic pathway involved in the catalytic cycle of the enzyme. Moreover, the use of F-19 NMR as a powerful analytical technique is described.

引用

页码：271 / 283

页数：13

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