Monoclonal antibodies against the nonmucin domain of institute MUC1/episialin

被引:9
作者
Hilkens, J [1 ]
Boer, M [1 ]
机构
[1] Netherlands Canc Inst, Div Tumor Biol, NL-1066 CX Amsterdam, Netherlands
关键词
monoclonal antibody specificity; MUC1;
D O I
10.1159/000056506
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We have tested the reactivity of the monoclonal antibodies submitted to the ISOBM TD-4 Workshop for reactivity with a hybrid molecule consisting of the bacterial beta-galactosidase and most of the extracellular nonrepeat domain of MUC1/episialin. Two monoclonal antibodies submitted to the Workshop, 232A1 and M29, were directed against the protein moiety of this domain as shown by immunoblotting and immunoprecipitation.
引用
收藏
页码:67 / 70
页数:4
相关论文
共 4 条
[1]   CELL MEMBRANE-ASSOCIATED MUCINS AND THEIR ADHESION-MODULATING PROPERTY [J].
HILKENS, J ;
LIGTENBERG, MJL ;
VOS, HL ;
LITVINOV, SV .
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (09) :359-363
[2]  
LIGTENBERG MJL, 1992, J BIOL CHEM, V267, P6171
[3]  
LIGTENBERG MJL, 1990, J BIOL CHEM, V265, P5573
[4]  
LIGTENBERG MJL, 1992, CANCER RES, V52, P2318