Signal processing underlying extrinsic control of stem cell fate

被引：13

作者：

Davey, RE ^{[1
]}

Zandstra, PW ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem Engn & Appl Chem, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada

来源：

CURRENT OPINION IN HEMATOLOGY | 2004年 / 11卷 / 02期

关键词：

stem cells; systems biology; signaling networks; extrinsic control;

D O I：

10.1097/01.moh.0000133650.68744.0c

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The authors review advances in the understanding of these underlying mechanisms, and discuss experimental and analytic tools necessary to investigate and use these mechanisms to control stem cell fate.

引用

页码：95 / 101

页数：7

共 55 条

[1]

Asthagiri AR, 2000, J CELL SCI, V113, P4499

[2] Distinct role of gp130 activation in promoting self-renewal divisions by mitogenically stimulated murine hematopoietic stem cells [J].

Audet, J ;

Miller, CL ;

Rose-John, S ;

Piret, JM ;

Eaves, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) :1757-1762

[3] Bistabillity in the JNK cascade [J].

Bagowski, CP ;

Ferrell, JE .

CURRENT BIOLOGY, 2001, 11 (15) :1176-1182

[4] Emergent properties of networks of biological signaling pathways [J].

Bhalla, US ;

Iyengar, R .

SCIENCE, 1999, 283 (5400) :381-387

[5] Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation [J].

Bhardwaj, G ;

Murdoch, B ;

Wu, D ;

Baker, DP ;

Williams, KP ;

Chadwick, K ;

Ling, LE ;

Karanu, FN ;

Bhatia, M .

NATURE IMMUNOLOGY, 2001, 2 (02) :172-180

[6] Wnt signaling: a common theme in animal development [J].

Cadigan, KM ;

Nusse, R .

GENES & DEVELOPMENT, 1997, 11 (24) :3286-3305

[7] Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

[8] Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells [J].

Chambers, I ;

Colby, D ;

Robertson, M ;

Nichols, J ;

Lee, S ;

Tweedie, S ;

Smith, A .

CELL, 2003, 113 (05) :643-655

[9] Dpp signaling silences bam transcription directly to establish asymmetric divisions of germline stem cells [J].

Chen, DH ;

McKearin, D .

CURRENT BIOLOGY, 2003, 13 (20) :1786-1791

[10] Differentiation hotspots: the deterioration of hierarchy and stochasm [J].

Colvin, GA ;

Lambert, JF ;

Abedi, M ;

Dooner, MS ;

Demers, D ;

Moore, BE ;

Greer, D ;

Aliotta, JM ;

Pimentel, J ;

Cerny, J ;

Lum, LG ;

Quesenberry, PJ .

BLOOD CELLS MOLECULES AND DISEASES, 2004, 32 (01) :34-41

← 1 2 3 4 5 6 →