The coupling of a trkB tyrosine residue to LTP

被引：60

作者：

Ernfors, P ^{[1
]}

Bramham, CR

机构：

[1] Karolinska Inst, MBB, Mol Neurobiol Unit, S-17177 Stockholm, Sweden

[2] Univ Bergen, Dept Physiol & Locus Neurosci, N-5009 Bergen, Norway

来源：

TRENDS IN NEUROSCIENCES | 2003年 / 26卷 / 04期

关键词：

D O I：

10.1016/S0166-2236(03)00064-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) and its receptor, trkB, activate cAMP-response-element-binding protein (CREB) and the transcription of genes that is crucial for long-term potentiation (LTP). Any of several signaling pathways activated by trkB could be required for LTP. A recent study using mice carrying a mutation in a specific tyrosine residue of trkB pinpoints a necessary role for the phospholipase-Cgamma (PLCgamma) pathway in CREB activation and LTP maintenance.

引用

页码：171 / 173

页数：3

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