Formation and spatio-temporal evolution of periodic structures in lipid bilayers

被引：72

作者：

Rozovsky, S ^{[1
]}

Kaizuka, Y ^{[1
]}

Groves, JT ^{[1
]}

机构：

[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 01期

关键词：

D O I：

10.1021/ja046300o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Miscibility phase separation in lipid bilayers is widely implicated as an organizing principle in living cell membranes. However, the chemical and physical aspects of how membrane phase separation modulates protein activity remain obscure. Herein, we describe formation of ordered superstructures of coexisting liquid phases in bilayer membranes. Metastable stripe and hexagonal domain lattices are observed, as well as transitions between them. The high degree of order achieved by these methods facilitates statistical analysis of domain spatial distributions and enables measurement of domain interactions. Such long-range ordering principles may exist in more complicated membrane systems. Copyright © 2005 American Chemical Society.

引用

页码：36 / 37

页数：2

共 13 条

[1] Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension [J].

Baumgart, T ;

Hess, ST ;

Webb, WW .

NATURE, 2003, 425 (6960) :821-824

[2]

GEBHARDT C, 1977, Z NATURFORSCH C, V32, P581

[3] SHAPE TRANSITIONS AND SHAPE STABILITY OF GIANT PHOSPHOLIPID-VESICLES IN PURE WATER INDUCED BY AREA-TO-VOLUME CHANGES [J].

KAS, J ;

SACKMANN, E .

BIOPHYSICAL JOURNAL, 1991, 60 (04) :825-844

[4]

KAWAKATSU T, 1993, J PHYS II, V3, P971, DOI 10.1051/jp2:1993177

[5] 3 DIMENSIONAL MICROSCOPIC SURFACE PROFILES OF MEMBRANES RECONSTRUCTED FROM FREEZE-ETCHING ELECTRON-MICROGRAPHS [J].

KRBECEK, R ;

GEBHARDT, C ;

GRULER, H ;

SACKMANN, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 554 (01) :1-22

[6] ORDERED AND CURVED MESO-STRUCTURES IN MEMBRANES AND AMPHIPHILIC FILMS [J].

LEIBLER, S ;

ANDELMAN, D .

JOURNAL DE PHYSIQUE, 1987, 48 (11) :2013-2018

[7] THE CONFORMATION OF MEMBRANES [J].

LIPOWSKY, R .

NATURE, 1991, 349 (6309) :475-481

[8] STRUCTURES AND TRANSITIONS IN LIPID MONOLAYERS AT THE AIR-WATER-INTERFACE [J].

MCCONNELL, HM .

ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1991, 42 :171-195

[9] Liquid-liquid immiscibility in membranes [J].

McConnell, HM ;

Vrljic, M .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2003, 32 :469-492

[10] Configurations of fluid membranes and vesicles [J].

Seifert, U .

ADVANCES IN PHYSICS, 1997, 46 (01) :13-137

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