Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid

被引：66

作者：

Rosenbaum, DM

Rosenbaum, PS

Gupta, A

Michaelson, MD

Hall, DH

Kessler, JA

机构：

[1] Albert Einstein Coll Med, Dept Neurol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Dept Ophthalmol & Visual Sci, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 USA

[4] Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA

来源：

VISION RESEARCH | 1997年 / 37卷 / 24期

关键词：

apoptosis; ischemia; retina; aurintricarboxylic acid;

D O I：

10.1016/S0042-6989(96)00328-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transient retinal ischemia results in a delayed cell death of the inner retinal layers. This study demonstrates that this ischemic cell death occurs, at least in part, through apoptosis. The general endonuclease inhibitor, aurintricarboxylic acid, protected rat retinal cells from ischemic cell damage when administered before the onset of ischemia and, more importantly, when administered 6 hr after the insult, Thus, the demonstration that transient retinal ischemia results in cell damage as a result of apoptosis opens new therapeutic strategies aimed at lessening retinal damage as a result of this process. (C) 1997 Elsevier Science Ltd.

引用

页码：3445 / 3451

页数：7

共 22 条

[1] AURINTRICARBOXYLIC ACID RESCUES PC12 CELLS AND SYMPATHETIC NEURONS FROM CELL-DEATH CAUSED BY NERVE GROWTH-FACTOR DEPRIVATION - CORRELATION WITH SUPPRESSION OF ENDONUCLEASE ACTIVITY [J].