共 47 条
Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors
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作者:

Epling-Burnette, Pearlie K.
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Bai, Fanqi
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Painter, Jeffrey S.
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Rollison, Dana E.
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Salih, Helmut R.
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Krusch, Matthias
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Zou, JianXiang
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Ku, Edna
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Zhong, Bin
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Boulware, David
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机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Moscinski, Lynn
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Wei, Sheng
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

Djeu, Julie Y.
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA

List, Alan F.
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h-index: 0
机构: Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA
机构:
[1] Univ S Florida, H Lee Moffitt Canc Ctr, Program Immunol, Tampa, FL 33612 USA
[2] Univ S Florida, H Lee Moffitt Canc Ctr, Hematol Malignancy Div, Tampa, FL 33612 USA
[3] James A Haley Vet Adm VA Hosp, Tampa, FL USA
[4] Univ S Florida, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA
[5] Univ S Florida, H Lee Moffitt Canc Ctr, Div Canc Prevent & Control, Tampa, FL 33612 USA
[6] Univ Tubingen, Univ Hosp, Dept Internal Med 2, D-72074 Tubingen, Germany
[7] Univ S Florida, H Lee Moffitt Canc Ctr, Biostat Program, Tampa, FL 33682 USA
来源:
关键词:
D O I:
10.1182/blood-2006-07-035519
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with potential for progression to acute myeloid leukemia (AML). We compared natural killer (NK) cytolytic function in 48 MDS patients with 37 healthy donors and found reduced activity in the patient population (K562 cytolysis, 19% +/- 21% SD versus 40% +/- 17%) (P <.001). NK cytotoxicity in MDS patients was reduced against 3 disparate tumor targets with differential activating receptor requirement, suggesting global defects in NK function. Reduced NK function in MDS was significantly associated with higher International Prognostic Score (P =.01), abnormal karyotype (P =.05), the presence of excess blasts (P =.01), and age-adjusted bone marrow hypercellularity (P =.04). MDS patients had a display of the activating receptor NKp30, and NKG2D down-regulation closely correlated with impaired NK function (P =.001). NKG2D ligands (MICA and MICB) were expressed on CD34(+) cells from bone marrow of 30% of MDS patients and a leukemic cell line derived from an MDS patient (MDS1). Collectively, these findings suggest that impairment of NK cytolytic function derives in part from reduced activating NK receptors such as NKG2D in association with disease progression. Evasion of NK immunosurveillance may have importance for MDS disease progression.
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页码:4816 / 4824
页数:9
相关论文
共 47 条
[1]
LYMPHOCYTE ABNORMALITIES IN PRELEUKEMIA .1. DECREASED NK ACTIVITY, ANOMALOUS IMMUNOREGULATORY CELL SUBSETS AND DEFICIENT EBV RECEPTORS
[J].
ANDERSON, RW
;
VOLSKY, DJ
;
GREENBERG, B
;
KNOX, SJ
;
BECHTOLD, T
;
KUSZYNSKI, C
;
HARADA, S
;
PURTILO, DT
.
LEUKEMIA RESEARCH,
1983, 7 (03)
:389-395

ANDERSON, RW
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

VOLSKY, DJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

GREENBERG, B
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

KNOX, SJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

BECHTOLD, T
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

KUSZYNSKI, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

HARADA, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105

PURTILO, DT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV NEBRASKA,MED CTR,EPPLEY INST RES CANC,OMAHA,NE 68105
[2]
Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors
[J].
Arase, H
;
Mocarski, ES
;
Campbell, AE
;
Hill, AB
;
Lanier, LL
.
SCIENCE,
2002, 296 (5571)
:1323-1326

Arase, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

Mocarski, ES
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

Campbell, AE
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

Hill, AB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

Lanier, LL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
[3]
Selective cross-talk among natural cytotoxicity receptors in human natural killer cells
[J].
Augugliaro, R
;
Parolini, S
;
Castriconi, R
;
Marcenaro, E
;
Cantoni, C
;
Nanni, M
;
Moretta, L
;
Moretta, A
;
Bottino, C
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2003, 33 (05)
:1235-1241

Augugliaro, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

论文数: 引用数:
h-index:
机构:

Castriconi, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

Marcenaro, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

Cantoni, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

Nanni, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

Moretta, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

Moretta, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy

Bottino, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Genoa, Dipartimento Med Sperimentale, Sez Istol, I-16132 Genoa, Italy
[4]
NK cell activation: Distinct stimulatory pathways counterbalancing inhibitory signals
[J].
Bakker, ABH
;
Wu, J
;
Phillips, JH
;
Lanier, LL
.
HUMAN IMMUNOLOGY,
2000, 61 (01)
:18-27

Bakker, ABH
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA

Wu, J
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA

Phillips, JH
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA

Lanier, LL
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA DNAX Res Inst Mol & Cellular Biol Inc, Dept Immunobiol, Palo Alto, CA 94304 USA
[5]
PRODUCTIVE NONLYTIC HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REPLICATION IN A NEWLY ESTABLISHED HUMAN LEUKEMIA-CELL LINE
[J].
BANERJEE, R
;
BEKESI, JG
;
TARCSAFALVI, A
;
SPERBER, K
;
DEAK, G
;
CHOI, HSH
;
PARONETTO, F
;
HOLLAND, JF
;
ACS, G
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1992, 89 (21)
:9996-10000

BANERJEE, R
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

BEKESI, JG
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

TARCSAFALVI, A
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

SPERBER, K
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

DEAK, G
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

CHOI, HSH
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

PARONETTO, F
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

HOLLAND, JF
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

ACS, G
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029
[6]
Activation of NK Cells and T Cells by NKG2D, a Receptor for Stress-Inducible MICA
[J].
Bauer, Stefan
;
Groh, Veronika
;
Wu, Jun
;
Steinle, Alexander
;
Phillips, Joseph H.
;
Lanier, Lewis L.
;
Spies, Thomas
.
JOURNAL OF IMMUNOLOGY,
2018, 200 (07)
:2231-2233

Bauer, Stefan
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
Tech Univ Munich, Inst Microbiol, Trogerstr 32, D-81675 Munich, Germany Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA

Groh, Veronika
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA

Wu, Jun
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA

Steinle, Alexander
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA

Phillips, Joseph H.
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA

Lanier, Lewis L.
论文数: 0 引用数: 0
h-index: 0
机构:
DNAX Res Inst Mol & Cellular Biol Inc, 901 Calif Ave, Palo Alto, CA 94304 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA

Spies, Thomas
论文数: 0 引用数: 0
h-index: 0
机构:
Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA Fred Hutchinson Canc Res Ctr, Div Clin Res, 1100 Fairview Ave North, Seattle, WA 98109 USA
[7]
ULBPs, novel MHC class I-related molecules bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor
[J].
Cosman, D
;
Müllberg, J
;
Sutherland, CL
;
Chin, W
;
Armitage, R
;
Fanslow, W
;
Kubin, M
;
Chalupny, NJ
.
IMMUNITY,
2001, 14 (02)
:123-133

Cosman, D
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Müllberg, J
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Sutherland, CL
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Chin, W
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Armitage, R
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Fanslow, W
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Kubin, M
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA

Chalupny, NJ
论文数: 0 引用数: 0
h-index: 0
机构: Immunex Corp, Dept Biol Mol, Seattle, WA 98101 USA
[8]
NK cells: innate immunity against hematological malignancies?
[J].
Costello, RT
;
Fauriat, C
;
Sivori, S
;
Marcenaro, E
;
Olive, D
.
TRENDS IN IMMUNOLOGY,
2004, 25 (06)
:328-333

Costello, RT
论文数: 0 引用数: 0
h-index: 0
机构: Ctr Lutte Contre Canc Marseille, Lab Immunol Tumeurs, F-13009 Marseille, France

Fauriat, C
论文数: 0 引用数: 0
h-index: 0
机构: Ctr Lutte Contre Canc Marseille, Lab Immunol Tumeurs, F-13009 Marseille, France

Sivori, S
论文数: 0 引用数: 0
h-index: 0
机构: Ctr Lutte Contre Canc Marseille, Lab Immunol Tumeurs, F-13009 Marseille, France

Marcenaro, E
论文数: 0 引用数: 0
h-index: 0
机构: Ctr Lutte Contre Canc Marseille, Lab Immunol Tumeurs, F-13009 Marseille, France

Olive, D
论文数: 0 引用数: 0
h-index: 0
机构: Ctr Lutte Contre Canc Marseille, Lab Immunol Tumeurs, F-13009 Marseille, France
[9]
Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia
[J].
Costello, RT
;
Sivori, S
;
Marcenaro, E
;
Lafage-Pochitaloff, M
;
Mozziconacci, MJ
;
Reviron, D
;
Gastaut, JA
;
Pende, D
;
Olive, D
;
Moretta, A
.
BLOOD,
2002, 99 (10)
:3661-3667

Costello, RT
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Sivori, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Marcenaro, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Lafage-Pochitaloff, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Mozziconacci, MJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Reviron, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Gastaut, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Pende, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Olive, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France

Moretta, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterranee, Inst Paoli Calmettes, Unite Immunol Tumeurs, Marseille, France
[10]
A novel mechanism of antitumor response involving the expansion of CD3+/CD56+ large granular lymphocytes triggered by a tumor-expressed activating ligand
[J].
Costello, RT
;
Sivori, S
;
Mallet, F
;
Sainty, D
;
Arnoulet, C
;
Reviron, D
;
Gastaut, JA
;
Moretta, A
;
Olive, D
.
LEUKEMIA,
2002, 16 (05)
:855-860

Costello, RT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Sivori, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Mallet, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Sainty, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Arnoulet, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Reviron, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Gastaut, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Moretta, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France

Olive, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Mediterrannee, Inst Paoli Calmettes, Unite Immunol Tumeurs, F-13009 Marseille, France