Highly efficient catalytic asymmetric epoxidation of allylic alcohols by an oxovanadium-substituted polyoxometalate with a regenerative TADDOL-derived hydroperoxide

被引：43

作者：

Adam, W

Alsters, PL

Neumann, R

Saha-Möller, CR

Seebach, D

Zhang, R ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

[2] Fine Chem Adv Synth & Catalysis, NL-6160 MD Geleen, Netherlands

[3] Weizmann Inst Sci, Dept Organ Chem, IL-76100 Rehovot, Israel

[4] ETH Honggerberg, HCI, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1021/ol027498p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The oxovanadium(IV) sandwich-type POM catalyzes the chemo-, regio-, and stereoselective epoxidation of allylic alcohols by chiral hydroperoxides with very high catalytic efficiency (up to 42 000 TON), a potentially valuable oxidation for the development of sustainable processes. By using the sterically demanding, TADDOL-derived hydroperoxide TADOOH as the chiral oxygen source, enantiomeric ratios (er) of up to 95:5 have been achieved.

引用

页码：725 / 728

页数：4

共 36 条

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Adam W, 2002, SYNLETT, P2011

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