Detection of two porcine circovirus type 2 genotypic groups in United States swine herds

被引:229
作者
Cheung, A. K.
Lager, K. M.
Kohutyuk, O. I.
Vincent, A. L.
Henry, S. C.
Baker, R. B.
Rowland, R. R.
Dunham, A. G.
机构
[1] USDA, Natl Anim Dis Ctr, Virus & Prion Dis Livestock Res Unit, Ames, IA 50010 USA
[2] Iowa State Univ, Dept Comp Sci, Ames, IA USA
[3] Abilene Anim Hosp PA, Abilene, KS USA
[4] N Carolina State Univ, Sch Vet Med, Raleigh, NC 27695 USA
[5] Kansas State Univ, Manhattan, KS 66506 USA
[6] Ryan Vet Serv, Ryan, IA USA
关键词
D O I
10.1007/s00705-006-0909-6
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In late 2005, sporadic cases of an acute onset disease of high mortality were observed in 10- to 16-week-old growing pigs among several swine herds of the United States. Tissues from the affected pigs in Kansas, Iowa, and North Carolina were examined, and porcine circovirus type 2 (PCV2) was detected consistently among these tissues. Phylogenetically, PCV2 can be divided into two major genotypic groups, PCV2-group 1 and PCV2-group 2. Whereas PCV2-group 1 isolates were detected in all the diseased animals, only two of the diseased animals harbored PCV2-group 2 isolates. This observation is important because PCV2-group 1 isolates had never been reported in the United States before (GenBank as of May 16, 2006), and they are closely related to the PCV2-group 1 isolates that have been described in Europe and Asia, previously. Our analysis revealed that each genotypic group contains a distinct stretch of nucleotide or amino acid sequence that may serve as a signature motif for PCV2-group 1 or PCV2-group 2 isolates.
引用
收藏
页码:1035 / 1044
页数:10
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