Synthesis of monoglucosylated high-mannose-type dodecasaccharide, a putative ligand for molecular chaperone, calnexin, and calreticurin

被引：124

作者：

Matsuo, I

Wada, M

Manabe, S

Yamaguchi, Y

Otake, K

Kato, K

Ito, Y

机构：

[1] RIKEN, Inst Phys & Chem Res, Wako, Saitama 3510198, Japan

[2] JST, CREST, Kawaguchi 3321102, Japan

[3] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 12期

关键词：

D O I：

10.1021/ja021288q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained. Copyright © 2003 American Chemical Society.

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页码：3402 / 3403

页数：2

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