A calmodulin-related protein that suppresses posttranscriptional gene silencing in plants

被引：254

作者：

Anandalakshmi, R

Marathe, R

Ge, X

Herr, JM

Mau, C

Mallory, A

Pruss, G

Bowman, L

Vance, VB ^{[1
]}

机构：

[1] Univ S Carolina, Dept Biol Sci, Columbia, SC 29208 USA

[2] Univ Calif Davis, CEPRAP, Davis, CA 95616 USA

来源：

SCIENCE | 2000年 / 290卷 / 5489期

关键词：

D O I：

10.1126/science.290.5489.142

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Posttranscriptional gene silencing (PTGS) is an ancient eukaryotic regulatory mechanism in which a particular RNA sequence is targeted and destroyed. The helper component-proteinase (HC-Pro) of plant potyviruses suppresses PTGS in plants; Using a yeast two-hybrid system, we identified a calmodulin-related protein (termed rgs-CaM) that interacts with HC-Pro. Here we report that rgs-CaM, like HC-Pro itself, suppresses gene silencing. Our work is the first report identifying a cellular suppressor of PTGS.

引用

页码：142 / 144

页数：3

共 25 条

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