Novel quinolone derivatives as potent antibacterials

被引：8

作者：

Lohray, BB

Baskaran, S

Rao, BS

Mallesham, B

Bharath, KSN

Reddy, BY

Venkateswarlu, S

Sadhukhan, AK

Kumar, MS

Sarnaik, HM

机构：

[1] Dr Reddys Res Fdn, Dept Med Chem & Drug Discovery, Hyderabad 500050, Andhra Pradesh, India

[2] Dr Reddys Res Fdn, Dept Biotechnol, Hyderabad 500050, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(98)00063-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 7-(3R,4R-N,N'-dialkyl diaminopyrrolidinyl)-substituted quinolones were synthesized and evaluated for antibacterial activities. 5-Amino-7-(3R,4R-N,N'-dimethyldiamino-6,8-difluoro-1,4-dihydro-1-cyclopropyl-4-oxoquinoline-3-carboxylic acid was found to have potent antibacterial activity against gram + ve organisms. (C) 1998 Elsevier Science Ltd. All rights reserved.

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收藏

页码：525 / 528

页数：4

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