Synthesis and biological studies of glycosyl dopamine derivatives as potential antiparkinsonian agents

被引：76

作者：

Fernández, C

Nieto, O

Rivas, E

Montenegro, G

Fontenla, JA

Fernández-Mayoralas, A

机构：

[1] CSIC, Inst Quim Organ Gen, E-28006 Madrid, Spain

[2] Univ Santiago Compostela, Fac Farm, Dept Farmacol, E-15706 Santiago De Compostela, Spain

来源：

CARBOHYDRATE RESEARCH | 2000年 / 327卷 / 04期

关键词：

glycosides; neurologically active compounds; neurotransmitter; glucose carrier;

D O I：

10.1016/S0008-6215(00)00073-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new approach to deliver dopamine into the central nervous system, based on the use of D-glucose as transportable agent, has been studied. Glycosyl dopamine derivatives bearing the sugar moiety linked to either the amino group or the catechol ring of dopamine through amide, eater or glycosidic bonds were synthesised as potential antiparkinsonian agents. Studies on the binding to dopamine D-2 receptor, in vitro stability, and locomotive effect in mice of the synthetic glycoconjugates are reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：353 / 365

页数：13

共 18 条

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