Sodium-calcium exchange: Recent advances

被引:43
作者
Hryshko, LV
Philipson, KD
机构
[1] UNIV CALIF LOS ANGELES, SCH MED, CARDIOVASC RES LAB, LOS ANGELES, CA 90095 USA
[2] ST BONIFACE GEN HOSP, RES CTR, DIV CARDIOVASC SCI, WINNIPEG, MB R2H 2A6, CANADA
关键词
sodium-calcium exchange; regulation; exchanger isoforms;
D O I
10.1007/BF00794067
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Na-Ca exchange proteins are involved in Ca homeostasis in a wide variety of tissues. Unique Na-Ca exchangers have been identified by molecular biological approaches and it appears that these may represent a superfamily of ion transporters, similar to that identified for ion channels. Major advances in our understanding of these transporters have occurred in the past decade by combining molecular approaches with electrophysiological analyses. The regulatory and transport properties of Na-Ca exchangers are beginning to become understood in molecular detail. It also appears that the physiological roles of Na-Ca exchange may be quite complex. This brief review highlights some recent advances in Na-Ca exchange research obtained through the combination of molecular biological and electrophysiological approaches.
引用
收藏
页码:45 / 51
页数:7
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