Continuous microfluidic immunomagnetic cell separation

被引：297

作者：

Inglis, DW ^{[1
]}

Riehn, R

Austin, RH

Sturm, JC

机构：

[1] Princeton Univ, Princeton Inst Sci & Technol, Dept Elect Engn, Princeton, NJ 08544 USA

[2] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA

来源：

APPLIED PHYSICS LETTERS | 2004年 / 85卷 / 21期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1063/1.1823015

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

We present a continuous-flow microfluidic device that enables cell by cell separation of cells selectively tagged with magnetic nanoparticles. The cells flow over an array of microfabricated magnetic stripes, which create a series of high magnetic field gradients that trap the magnetically labeled cells and alter their flow direction. The process was observed in real time using a low power microscope. The device has been demonstrated by the separation of leukocytes from whole human blood. (C) 2004 American Institute of Physics.

引用

页码：5093 / 5095

页数：3

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