Association study of Toll-like receptor 9 gene polymorphism in Korean patients with systemic lupus erythematosus

被引：78

作者：

Hur, JW

Shin, HD

Park, BL

Kim, LH

Kim, SY

Bae, SC

机构：

[1] Hanyang Univ, Med Ctr, Hosp Rheumat Dis, Dept Internal Med,Div Rheumatol, Seoul 133792, South Korea

[2] SNP Genet Inc, Dept Genet Epidemiol, Seoul, South Korea

[3] Kyungpook Natl Univ, Coll Med, Dept Orthoped Surg, Taegu, South Korea

来源：

TISSUE ANTIGENS | 2005年 / 65卷 / 03期

关键词：

polymorphism; systemic lopus erythematosus; TLR9;

D O I：

10.1111/j.1399-0039.2005.00374.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mammalian Toll-like receptors (TLR) play an important role in both adaptive immunity and innate immunity. Genetic variations within TLR genes are known to be associated with a variety of inflammatory and infectious diseases. TLR9 is potentially associated with autoimmune diseases, because it participates in the production of pro-inflammatory cytokines and the maturation of dendritic cells. We investigated the association of four TLR9 gene polymorphisms (-1486 T>C, -1237 C>T, +1174 A>G and +2848 G>A) with the susceptibility to systemic lupus erythematosus (SLE) and related phenotypes in 680 Korean people (350 SLE patients and 330 controls). TLR9 gene polymorphisms were not significantly associated with the susceptibility to SLE and related phenotypes.

引用

页码：266 / 270

页数：5

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