A polymorphism upstream from the human paraoxonase (PON1) gene and its association with PON1 expression

被引：131

作者：

Suehiro, T

Nakamura, T

Inoue, M

Shiinoki, T

Ikeda, Y

Kumon, Y

Shindo, M

Tanaka, H

Hashimoto, K

机构：

[1] Kochi Med Sch, Dept Internal Med 2, Nanko Ku, Kochi 7818505, Japan

[2] Japan Tobacco Inc, Cent Pharmaceut Res Inst, Takatsuki, Osaka 5691125, Japan

来源：

ATHEROSCLEROSIS | 2000年 / 150卷 / 02期

关键词：

paraoxonase; lipid peroxidation; genetic polymorphism; coronary heart disease;

D O I：

10.1016/S0021-9150(99)00379-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human serum paraoxonase (PON1) is an esterase that has been shown to decrease the susceptibility of lipoproteins to lipid peroxidation. We found a polymorphism of cytosine/thymidine (- 108C/T, the number is from the ATG codon) in the upstream region of the PON1 gene. The luciferase activity was lower in the - 108T allele than in the - 108C allele. The serum PONI concentrations in 132 normal subjects were as follows: - 108CC > - 108CT and > - 108TT genotypes. The polymorphism upstream from the PON1 gene is associated with transcription of the PON1 gene and the serum PON1 concentration. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：295 / 298

页数：4

共 17 条

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