Obesity and dementia: Adipokines interact with the brain

被引：174

作者：

Arnoldussen, Ilse A. C. ^{[1
]}

Kiliaan, Amanda J. ^{[1
]}

Gustafson, Deborah R. ^{[2
,3
,4
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Anat, Donders Inst Brain Cognit & Behav, NL-6525 EZ Nijmegen, Netherlands

[2] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA

[3] Inserm Versailles St Quentin, UMS 011, Versailles, France

[4] Univ Gothenburg, Sahlgrenska Acad, Sect Psychiat & Neurochem,Neuropsychiat Epidemiol, NeuroPsychiat Epidemiol Unit,Inst Neurosci & Phys, S-43141 Gothenburg, Sweden

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2014年 / 24卷 / 12期

基金：

瑞典研究理事会;

关键词：

Obesity; Adipokinesi; Brain; Leptin; Alzheimer; Dementia; TUMOR-NECROSIS-FACTOR; RENIN-ANGIOTENSIN SYSTEM; PLASMINOGEN-ACTIVATOR INHIBITOR-1; BODY-MASS INDEX; LONG-TERM POTENTIATION; MILD COGNITIVE IMPAIRMENT; HUMAN CEREBROSPINAL-FLUID; CENTRAL-NERVOUS-SYSTEM; VASCULAR RISK-FACTORS; NF-KAPPA-B;

D O I：

10.1016/j.euroneuro.2014.03.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Obesity is a pandemic and a serious global health concern. Obesity is a risk factor for multiple conditions and contributes to multi-morbidities, resulting in increased health costs and millions of deaths each year. Obesity has been associated with changes in brain structure, cognitive deficits, dementia and Alzheimer's disease. Adipokines, defined as hormones, cytokines and peptides secreted by adipose tissue, may have more widespread influence and functionality in the brain than previously thought. In this review, six adipokines, and their actions in the obese and non-obese conditions will be discussed. Included are: plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factors alpha (TNF-alpha), angiotensinogen (AGT), adiponectin and leptin. Their functionality in the periphery, their ability to cross the blood brain barrier (BBB) and their influence on dementia processes within the brain will be discussed. (C) 2014 Elsevier By, and ECNP. All rights reserved.

引用

页码：1982 / 1999

页数：18

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