A novel role for an established player:: anemia drug erythropoietin for the treatment of cerebral hypoxia/ischemia

被引：23

作者：

Ehrenreich, H ^{[1
]}

Timner, W ^{[1
]}

Sirén, AL ^{[1
]}

机构：

[1] Max Planck Inst Expt Med, D-37075 Gottingen, Germany

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2004年 / 31卷 / 01期

关键词：

D O I：

10.1016/j.transci.2004.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Erythropoietin, a hematopoietic growth-factor possessing manifold, potent neuroprotective properties, after multiple testing in cell culture and animal studies now gradually finds its way into clinical neuroscience. The first time this took place was in 1998 with a pilot study in stroke patients, the "Gottingen EPO-Stroke-Trial". This study was able to demonstrate that EPO is perfectly well tolerated and safe with this indication. Furthermore, the EPO-treated patients showed a significantly better outcome regarding their clinical progress as well as regarding the infarct size as observed by MRI, when compared to the placebo treated patients. At the moment a multicenter study is being carried out in Germany. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：39 / 44

页数：6

共 29 条

[1] Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis [J].

Agnello, D ;

Bigini, P ;

Villa, P ;

Mennini, T ;

Cerami, A ;

Brines, ML ;

Ghezzi, P .

BRAIN RESEARCH, 2002, 952 (01) :128-134

[2] A potential role for erythropoietin in focal permanent cerebral ischemia in mice [J].

Bernaudin, M ;

Marti, HH ;

Roussel, S ;

Divoux, D ;

Nouvelot, A ;

MacKenzie, E ;

Petit, E .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1999, 19 (06) :643-651

[3] Erythropoietin both protects from and reverses experimental diabetic neuropathy [J].

Bianchi, R ;

Buyukakilli, B ;

Brines, M ;

Savino, C ;

Cavaletti, G ;

Oggioni, N ;

Lauria, G ;

Borgna, M ;

Lombardi, R ;

Cimen, B ;

Comelekoglu, U ;

Kanik, A ;

Tataroglu, C ;

Cerami, A ;

Ghezzi, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (03) :823-828

[4] Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury [J].

Brines, ML ;

Ghezzi, P ;

Keenan, S ;

Agnello, D ;

de Lanerolle, NC ;

Cerami, C ;

Itri, LM ;

Cerami, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10526-10531

[5] Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury [J].

Celik, M ;

Gökmen, N ;

Erbayraktar, S ;

Akhisaroglu, M ;

Konakç, S ;

Ulukus, C ;

Genc, S ;

Genc, K ;

Sagiroglu, E ;

Cerami, A ;

Brines, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2258-2263

[6] Protective effect of erythropoietin on the oxidative damage of erythrocyte membrane by hydroxyl radical [J].

Chattopadhyay, A ;

Das Choudhury, T ;

Bandyopadhyay, D ;

Datta, AG .

BIOCHEMICAL PHARMACOLOGY, 2000, 59 (04) :419-425

[7] Selfotel in acute ischemic stroke - Possible neurotoxic effects of an NMDA antagonist [J].

Davis, SM ;

Lees, KR ;

Albers, GW ;

Diener, HC ;

Markabi, S ;

Karlsson, G ;

Norris, J .

STROKE, 2000, 31 (02) :347-354

[8] Ischemic tolerance and endogenous neuroprotection [J].

Dirnagl, U ;

Simon, RP ;

Hallenbeck, JM .

TRENDS IN NEUROSCIENCES, 2003, 26 (05) :248-254

[9] Erythropoietin therapy for acute stroke is both safe and beneficial [J].

Ehrenreich, H ;

Hasselblatt, M ;

Dembowski, C ;

Cepek, L ;

Lewczuk, P ;

Stiefel, M ;

Rustenbeck, HH ;

Breiter, N ;

Jacob, S ;

Knerlich, F ;

Bohn, M ;

Poser, W ;

Rüther, E ;

Kochen, M ;

Gefeller, O ;

Gleiter, C ;

Wessel, TC ;

De Ryck, M ;

Itri, L ;

Prange, H ;

Cerami, A ;

Brines, M ;

Sirén, AL .

MOLECULAR MEDICINE, 2002, 8 (08) :495-505

[10] Erythropoietin:: a candidate compound for neuroprotection in schizophrenia [J].

Ehrenreich, H ;

Degner, D ;

Meller, J ;

Brines, M ;

Béhé, M ;

Hasselblatt, M ;

Woldt, H ;

Falkai, P ;

Knerlich, F ;

Jacob, S ;

von Ahsen, N ;

Maier, W ;

Brück, W ;

Rüther, E ;

Cerami, A ;

Becker, W ;

Sirén, AL .

MOLECULAR PSYCHIATRY, 2004, 9 (01) :42-54

← 1 2 3 →