Current strategies for retarding progression of renal disease

被引：52

作者：

Mackenzie, HS

Brenner, BM

机构：

[1] Brigham & Womens Hosp, Dept Med, Div Renal, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Boston, MA USA

来源：

AMERICAN JOURNAL OF KIDNEY DISEASES | 1998年 / 31卷 / 01期

关键词：

angiotensin-converting enzyme inhibitors; chronic renal disease; strategies;

D O I：

10.1053/ajkd.1998.v31.pm9428469

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Physiological insights gained in the 1980s into mechanisms of disease progression in experimental chronic nephropathies established the basis for therapeutic interventions to retard the progression of chronic renal disease in humans, In the 1990s, several large-scale clinical trials have confirmed the renoprotective effects of angiotensin-converting enzyme inhibitors in diabetic and nondiabetic nephropathies, Other studies have afforded strong support for the efficacy of dietary protein restriction in certain settings and underscored the importance of blood pressure control in proteinuric individuals, These interventions form the core of current strategies designed to preserve kidney function in patients with chronic renal disease, (C) 1998 by the National Kidney Foundation, Inc.

引用

页码：161 / 170

页数：10

共 46 条

[1]

Addis T., 1948, Glomerular Nephritis: Diagnosis and Treatment

[2] THERAPEUTIC ADVANTAGE OF CONVERTING ENZYME-INHIBITORS IN ARRESTING PROGRESSIVE RENAL-DISEASE ASSOCIATED WITH SYSTEMIC HYPERTENSION IN THE RAT [J].