Estrogen receptor-α expression in nociceptive-responsive neurons in the medullary dorsal horn of the female rat

被引:22
作者
Amandusson, Asa [1 ]
Blomqvist, Anders [1 ]
机构
[1] Linkoping Univ, Fac Hlth Sci, Dept Clin & Expt Med, Div Cell Biol, S-58185 Linkoping, Sweden
基金
瑞典研究理事会;
关键词
Estrogen receptor; Spinal trigeminal nucleus; Gonadal hormone; Pain; Fos; PREPROENKEPHALIN MESSENGER-RNA; TRIGEMINAL SENSORY SYSTEM; FOS-LIKE IMMUNOREACTIVITY; SPINAL-CORD; SUBNUCLEAR LOCALIZATION; PARABRACHIAL NUCLEUS; PERIAQUEDUCTAL GRAY; PAIN; STIMULATION; ESTRADIOL;
D O I
10.1016/j.ejpain.2009.05.008
中图分类号
R614 [麻醉学];
学科分类号
100217 [麻醉学];
摘要
Estrogens exert a substantial influence on the transmission of nociceptive stimuli and the susceptibility to pain disorders as made evident by studies in both animals and human subjects. The estrogen receptor ( ER) seems to be of crucial importance to the cellular mechanisms underlying such an influence. However, it has not been clarified whether nociceptive neurons activated by pain express ERs. In this study, a noxious injection of formalin was given into the lower lip of female rats, thereby activating nociceptive neurons in the trigeminal subnucleus caudalis as demonstrated by immunohistochemical labeling of Fos. Using a dual-label immunohistochemistry protocol ER alpha-containing cells were visualized in the same sections. In the superficial layers of the medullary dorsal horn, 12% of ER alpha-labeled cells, mainly located in lamina II, also expressed noxious-induced Fos. These findings show that nociceptive-responsive neurons in the medullary dorsal horn express ER alpha, thus providing a possible morphological basis for the hypothesis that estrogens directly regulate pain transmission at this level. (C) 2009 European Federation of International Association for the Study of Pain Chapters. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:245 / 248
页数:4
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