Inhibition of leukocyte adhesion:: an alternative mechanism of action for anti-inflammatory drugs

被引：61

作者：

Díaz-González, F

Sánchez-Madrid, F

机构：

[1] Univ Autonoma Madrid, Hosp Princesa, Serv Rheumatol, Madrid 28006, Spain

[2] Univ Autonoma Madrid, Hosp Princesa, Serv Immunol, Madrid 28006, Spain

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 04期

关键词：

D O I：

10.1016/S0167-5699(97)01216-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It has been widely accepted that the mechanism of action of nonsteroidal anti-inflammatory drugs (NSAIDs) is the inhibition of prostaglandin synthesis. However, a significant body of evidence suggests that NSAIDs have additional anti-inflammatory mechanisms of action. Here, Federico Diaz-Gonzalez and Francisco Sanchez-Madrid discuss novel effects of NSAIDs on leukocyte adhesion pathways that may help in the development of new anti-inflammatory agents that selectively block cell adhesion molecules.

引用

页码：169 / 172

页数：4

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[1] INHIBITION OF NEUTROPHIL FUNCTION BY ASPIRIN-LIKE DRUGS (NSAIDS) - REQUIREMENT FOR ASSEMBLY OF HETEROTRIMERIC G-PROTEINS IN BILAYER PHOSPHOLIPID [J].