How to use nitrates

被引:17
作者
Abrams, J [1 ]
机构
[1] Univ New Mexico, Hlth Sci Ctr, Div Cardiol, Dept Internal Med, Albuquerque, NM 87131 USA
关键词
nitrates; organic nitrates; nitrate tolerance; angina pectoris; nitrate-sildenafil interaction;
D O I
10.1023/A:1022982213484
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Nitrates are old drugs, available in many formulations, that are effective in relieving symptoms in various CAD syndromes as well as congestive heart failure. Nitrate tolerance is the major problem limiting nitrate efficacy and use by physicians. Currently, an intermittent dosing strategy is the only practical way to limit the development of tolerance or attenuation of nitrate actions.
引用
收藏
页码:511 / 514
页数:4
相关论文
共 11 条
[1]   Tolerance: An historical overview [J].
Abrams, J ;
Elkayam, U ;
Thadani, U ;
Fung, HL .
AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (1A) :3A-14A
[2]   Use of sildenafil (Viagra) in patients with cardiovascular disease [J].
Cheitlin, MD ;
Hutter, AM ;
Brindis, RG ;
Ganz, P ;
Kaul, S ;
Russell, RO ;
Zusman, RM ;
Forrester, JS ;
Douglas, PS ;
Faxon, DP ;
Fisher, JD ;
Gibbons, RJ ;
Halperin, JL ;
Hochman, JS ;
Kaul, S ;
Weintraub, WS ;
Winters, WL ;
Wolk, MJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1999, 33 (01) :273-282
[3]  
DEMOTS H, 1989, J AM COLL CARDIOL, V13, P786, DOI 10.1016/0735-1097(89)90216-7
[4]   Oral sildenafil in the treatment of erectile dysfunction [J].
Goldstein, I ;
Lue, TF ;
Padma-Nathan, H ;
Rosen, RC ;
Steers, WD ;
Wicker, PA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (20) :1397-1404
[5]  
Kanamasa K, 1998, CIRCULATION, V98, P637
[6]   Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies [J].
Nakamura, Y ;
Moss, AJ ;
Brown, MW ;
Kinoshita, M ;
Kawai, C .
AMERICAN HEART JOURNAL, 1999, 138 (03) :577-585
[7]   Nitrate therapy for stable angina pectoris [J].
Parker, JD ;
Parker, JO .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (08) :520-531
[8]   Sildenafil for treatment of erectile dysfunction in men with diabetes - A randomized controlled trial [J].
Rendell, MS ;
Rajfer, J ;
Wicker, PA ;
Smith, MD .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (05) :421-426
[9]   Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failure [J].
Thadani, U .
CARDIOVASCULAR DRUGS AND THERAPY, 1997, 10 (06) :735-742
[10]   Sildenafil citrate potentiates the hypotensive effects of nitric oxide donor drugs in male patients with stable angina [J].
Webb, DJ ;
Muirhead, GJ ;
Wulff, M ;
Sutton, JA ;
Levi, R ;
Dinsmore, WW .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (01) :25-31