A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus

被引：184

作者：

Partida-Martinez, Laila P.

Hertweck, Christian

机构：

[1] Leibniz Inst Nat Prod Res & Infect Biol, HKI, Dept Biomol Chem, D-07745 Jena, Germany

[2] Univ Jena, D-6900 Jena, Germany

来源：

CHEMBIOCHEM | 2007年 / 8卷 / 01期

关键词：

antimitotic agents; biosynthesis; natural products; polyketides; symbiosis;

D O I：

10.1002/cbic.200600393

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cloning, sequencing and gene analysis of the rhi gene locus in the genome of the rhizoxin-producing bacterial endosymbiont "Burkholderia rhizoxina" of the rice-pathogenic fungus Rhizopus microsporus provides the first insight into the giant trans-AT NRPS-PKS thiotemplate assembly line for the potent antimitotic macrolide. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：41 / 45

页数：5

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