Proteins as nano-machines: dynamics-function relations studied by neutron scattering

被引：9

作者：

Zaccai, G

机构：

[1] CEA CNRS, Inst Biol Struct, F-38027 Grenoble 1, France

[2] Inst Laue Langevin, F-38027 Grenoble, France

来源：

JOURNAL OF PHYSICS-CONDENSED MATTER | 2003年 / 15卷 / 18期

关键词：

D O I：

10.1088/0953-8984/15/18/301

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

A protein is a nano-machine whose molecular structure was selected by evolution to perform specific biological functions. Neutron spectroscopy is uniquely suited to provide experimental data on atomic motions in a protein under the influence of forces that maintain its stable and active molecular structure. Experiments are reviewed relating such a dynamics to soluble protein folding and stability in different environments, and to the activity of bacteriorhodopsin, a membrane protein nano-machine with light-driven proton pump activity.

引用

收藏

页码：S1673 / S1682

页数：10

相关论文

共 21 条

[1] STABILITY AGAINST DENATURATION MECHANISMS IN HALOPHILIC MALATE-DEHYDROGENASE ADAPT TO SOLVENT CONDITIONS [J].

BONNETE, F ;

MADERN, D ;

ZACCAI, G .

JOURNAL OF MOLECULAR BIOLOGY, 1994, 244 (04) :436-447

[2] A view of dynamics changes in the molten globule-native folding step by quasielastic neutron scattering [J].

Bu, ZM ;

Neumann, DA ;

Lee, SH ;

Brown, CM ;

Engelman, DM ;

Han, CC .

JOURNAL OF MOLECULAR BIOLOGY, 2000, 301 (02) :525-536

[3] Dynamic regimes and correlated structural dynamics in native and denatured alpha-lactalbumin [J].

Bu, ZM ;

Cook, J ;

Callaway, DJE .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 312 (04) :865-873

[4] Harmonic behavior of trehalose-coated carbon-monoxy-myoglobin at high temperature [J].

Cordone, L ;

Ferrand, M ;

Vitrano, E ;

Zaccai, G .

BIOPHYSICAL JOURNAL, 1999, 76 (02) :1043-1047

[5] Crystal structure of the EF-hand parvalbumin at atomic resolution (0.91Å) and at low temperature (100 K).: Evidence for conformational multistates within the hydrophobic core [J].

Declercq, JP ;

Evrard, C ;

Lamzin, V ;

Parello, J .

PROTEIN SCIENCE, 1999, 8 (10) :2194-2204

[6] DYNAMICAL TRANSITION OF MYOGLOBIN REVEALED BY INELASTIC NEUTRON-SCATTERING [J].

DOSTER, W ;

CUSACK, S ;

PETRY, W .

NATURE, 1989, 337 (6209) :754-756

[7] Molecular motions and hydration of purple membranes and disk membranes studied by neutron scattering [J].

Fitter, J ;

Ernst, OP ;

Hauss, T ;

Lechner, RE ;

Hofmann, KP ;

Dencher, NA .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1998, 27 (06) :638-645

[8] Dynamics and function of proteins: The search for general concepts [J].

Frauenfelder, H ;

McMahon, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :4795-4797

[9] Protein dynamics studied by neutron scattering [J].

Gabel, F ;

Bicout, D ;

Lehnert, U ;

Tehei, M ;

Weik, M ;

Zaccai, G .

QUARTERLY REVIEWS OF BIOPHYSICS, 2002, 35 (04) :327-367

[10]

GIRGORIEFF N, 1995, J MOL BIOL, V259, P393