Myeloid lineage commitment from the hematopoietic stem cell

被引：275

作者：

Iwasaki, Hirorni

Akashi, Koichi ^{[1
]}

机构：

[1] Kyushu Univ Hosp, Ctr Cellular & Mol Med, Fukuoka 8128582, Japan

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

来源：

IMMUNITY | 2007年 / 26卷 / 06期

关键词：

D O I：

10.1016/j.immuni.2007.06.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Prospective isolation of hematopoietic stem and progenitor cells has identified the lineal relationships among all blood-cell types and has allowed their developmental mechanisms to be assayed at the single-cell level. These isolated cell populations are used to elucidate the molecular mechanism of lineage fate decision and of its plasticity directly by stage-specific enforcement or repression of lineage-instructive signaling in purified cells. With an emphasis on the myeloid lineage, this review summarizes current concepts and controversies regarding adult murine hematopoietic development and discusses the potential mechanisms, operated by single or by multiple transcription factors, of myeloid lineage fate decision.

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收藏

页码：726 / 740

页数：15

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