Congenic mice: Cutting tools for complex immune disorders

被引：65

作者：

Rogner, UC ^{[1
]}

Avner, P ^{[1
]}

机构：

[1] Inst Pasteur, Unite Genet Mol Murine, F-75015 Paris, France

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 03期

关键词：

D O I：

10.1038/nri1031

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoimmune diseases are, in general, under complex genetic control and subject to strong interactions between genetics and the environment. Greater knowledge of the underlying genetics will provide immunologists with a framework for study of the immune dysregulation that occurs in such diseases. Ascertaining the number of genes that are involved and their characterization have, however, proven to be difficult. Improved methods of genetic analysis and the availability of a draft sequence of the complete mouse genome have markedly improved the outlook for such research, and they have emphasized the advantages of mice as a model system. In this review, we provide an overview of the genetic analysis of autoimmune diseases and of the crucial role of congenic and consomic mouse strains in such research.

引用

页码：243 / 252

页数：10

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