Icariin-loaded sulfonated polyetheretherketone with osteogenesis promotion and osteoclastogenesis inhibition properties via immunomodulation for advanced osseointegration

被引：37

作者：

Chai, Haobu ^{[1
]}

Sang, Shang ^{[1
]}

Luo, Yao ^{[1
]}

He, Renke ^{[1
]}

Yuan, Xiangwei ^{[1
]}

Zhang, Xianlong ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2022年 / 10卷 / 18期

基金：

中国国家自然科学基金;

关键词：

GROWTH-FACTOR; TGF-BETA; IN-VIVO; BONE; DIFFERENTIATION; TITANIUM; PEEK; IMPLANTS; PROGRESS; ROLES;

D O I：

10.1039/d1tb02802b

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Preventing prosthesis loosening due to insufficient osseointegration is critical for patients with osteoporosis. Endowing implants with immunomodulatory function can effectively enhance osseointegration. In this work, we loaded icariin (ICA) onto 3D porous sulfonated PEEK (SPEEK) via polydopamine (PDA) modification. Modified ICA-PDA@SPEEK not only promoted the polarization of macrophages to the anti-inflammatory M2 type, but also enhanced the osteogenesis of bone mesenchymal stem cells (BMSCs) and inhibited RANKL-induced osteoclastogenesis by regulating cytokine from macrophages. In vivo experiments further showed that ICA-PDA@SPEEK regulated the host immune response and promoted osseointegration in ovariectomized (OVX) rats. The above results demonstrated that ICA-PDA@SPEEK could be an excellent orthopedic biomaterial with immunomodulatory properties.

引用

页码：3531 / 3540

页数：10

共 67 条

[1]

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