Regulation of cytoskeletal organization by syndecan transmembrane proteoglycans

被引:135
作者
Yoneda, A [1 ]
Couchman, JR [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Div Biomed Sci, London SW7 2AZ, England
关键词
syndecans; microfilament; extracellular matrix; cell adhesion;
D O I
10.1016/S0945-053X(03)00010-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Syndecans, a family of transmembrane proteoglycans, interact with numerous extracellular ligands through specific sequences in their heparan sulfate chains and have been considered to be co-receptors for matrix molecules and growth factors. In addition to their roles as co-receptors, many studies have recently suggested that signaling through core protein of syndecans can regulate cytoskeletal organization through their clustering, association with cytoskeletal structures, binding to cytoplasmic binding proteins, and intracellular phosphorylation. Here we will review current understanding of signaling through syndecans in cytoskeletal organization. (C) 2003 Elsevier Science B.V./International Society of Matrix Biology. All rights reserved.
引用
收藏
页码:25 / 33
页数:9
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