The effectiveness of warfarin dosing from a nomogram compared with house staff dosing

被引：29

作者：

Asnis, Peter D.

Gardner, Michael J.

Ranawat, Anil

Leitzes, Anne H.

Peterson, Margaret G. E.

Bass, Anne R.

机构：

[1] Hosp Special Surg, Dept Med, New York, NY 10021 USA

[2] Hosp Special Surg, Dept Orthoped Surg, New York, NY 10021 USA

来源：

JOURNAL OF ARTHROPLASTY | 2007年 / 22卷 / 02期

关键词：

warfarin; nomogram; arthroplasty; thromboembolism; orthopedic; anticoagulation;

D O I：

10.1016/j.arth.2006.03.006

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The purpose of this study is to address the safety and efficacy of a warfarin dosing nomogram. Patients undergoing hip or knee arthroplasty were randomized to warfarin dosed by nomogram (n = 106) or by house staff (n = 110) during their hospital stay. The average daily dose of warfarin was 4.14 mg for the nomogram group and 4.18 mg for the house staff group. On postoperative day 4, the average international normalized ratio was 1.55 in the nomogram group compared with 1.59 in the house staff group. On postoperative day 4, 19.1% of the patients in the nomogram group had a therapeutic international normalized ratio, compared with 14.7% in the house staff group. There were no differences in bleeding or thrombotic complications in the 2 groups. This nomogram appears to be both safe and effective.

引用

页码：213 / 218

页数：6

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