Cell adhesion and chemotaxis in prostate cancer metastasis to bone: a minireview

被引：45

作者：

Cooper, CR ^{[1
]}

Pienta, KJ ^{[1
]}

机构：

[1] Univ Michigan, Dept Internal Med, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2000年 / 3卷 / 01期

关键词：

cell adhesion molecules; cytokines; human bone marrow endothelial cells; chemoattractants; prostate cancer cells;

D O I：

10.1038/sj.pcan.4500387

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Bone metastasis is a common phenomenon in patients with advanced prostate cancer The molecular and cellular mechanisms involved in this process are not well understood. Past reviews on this subject primarily focused on prostate tumor growth in the bone marrow and the effects this growth has on bone homeostasis (ie osteoblastic and osteolytic). Cell chemotaxis and adhesion are also important for site-specific metastasis. In this review we have focused on chemotactic and cell adhesion molecules potentially involved in prostate cancer metastasis to bone. In addition, recently developed animal models for prostate cancer metastasis to bone are discussed.

引用

页码：6 / 12

页数：7

共 52 条

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