Granulocytic ehrlichiosis in the laboratory mouse

被引:65
作者
Hodzic, E
IJdo, JWI
Feng, SL
Katavolos, P
Sun, W
Maretzki, CH
Fish, D
Fikrig, E
Telford, SR
Barthold, SW
机构
[1] Univ Calif Davis, Ctr Comparat Med, Sch Med, Davis, CA 95616 USA
[2] Univ Calif Davis, Sch Vet Med, Davis, CA 95616 USA
[3] Yale Univ, Sch Med, Dept Internal Med, Rheumatol Sect, New Haven, CT 06510 USA
[4] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Trop Publ Hlth, Boston, MA 02115 USA
关键词
D O I
10.1086/514236
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
C3H mice that were inoculated with ehrlichiae isolated from a patient with human granulocytic ehrlichiosis (HGE) developed anemia and leukopenia, but by day 24, they returned to normal values. Granulocytic morulae were present in peripheral blood and spleen smears on days 5 and 10, and there was a reduction in morulae on day 17. Ehrlichiae mere present in HL-60 cell cultures of blood and spleen from all mice at all intervals. Pathogenicity, but not infectivity, waned with mouse passage but could be resurrected by SCID mouse passage. Various methods were tested for their relative sensitivity in detecting infection: blood smears, HL-60 cell cultures, polymerase chain reaction (PCR) amplification of a 16S recombinant DNA target, and a mouse infectivity assay, All assays detected the HGE agent in blood during early infection, but PCR and the mouse infectivity assay were most sensitive during late infection. Xenodiagnosis demonstrated that mice remain persistently infected through 55 days.
引用
收藏
页码:737 / 745
页数:9
相关论文
共 25 条
[1]   AMBLYOMMA-AMERICANUM - A POTENTIAL VECTOR OF HUMAN EHRLICHIOSIS [J].
ANDERSON, BE ;
SIMS, KG ;
OLSON, JG ;
CHILDS, JE ;
PIESMAN, JF ;
HAPP, CM ;
MAUPIN, GO ;
JOHNSON, BJB .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 49 (02) :239-244
[2]   EHRLICHIA-EWINGII SP-NOV, THE ETIOLOGIC AGENT OF CANINE GRANULOCYTIC EHRLICHIOSIS [J].
ANDERSON, BE ;
GREENE, CE ;
JONES, DC ;
DAWSON, JE .
INTERNATIONAL JOURNAL OF SYSTEMATIC BACTERIOLOGY, 1992, 42 (02) :299-302
[3]   EHRLICHIA-CHAFFEENSIS, A NEW SPECIES ASSOCIATED WITH HUMAN EHRLICHIOSIS [J].
ANDERSON, BE ;
DAWSON, JE ;
JONES, DC ;
WILSON, KH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (12) :2838-2842
[4]   Clinical and laboratory characteristics of human granulocytic ehrlichiosis [J].
Bakken, JS ;
Krueth, J ;
WilsonNordskog, C ;
Tilden, RL ;
Asanovich, K ;
Dumler, JS .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1996, 275 (03) :199-205
[5]   HUMAN GRANULOCYTIC EHRLICHIOSIS IN THE UPPER MIDWEST UNITED-STATES - A NEW SPECIES EMERGING [J].
BAKKEN, JS ;
DUMLER, JS ;
CHEN, SM ;
ECKMAN, MR ;
VANETTA, LL ;
WALKER, DH .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (03) :212-218
[6]   HUMAN GRANULOCYTIC EHRLICHIOSIS IN EUROPE [J].
BROUQUI, P ;
DUMLER, JS ;
LIENHARD, R ;
BROSSARD, M ;
RAOULT, D .
LANCET, 1995, 346 (8977) :782-783
[7]   IDENTIFICATION OF A GRANULOCYTOTROPIC EHRLICHIA SPECIES AS THE ETIOLOGIC AGENT OF HUMAN-DISEASE [J].
CHEN, SM ;
DUMLER, JS ;
BAKKEN, JS ;
WALKER, DH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1994, 32 (03) :589-595
[8]   IDENTIFICATION OF THE ANTIGENIC CONSTITUENTS OF EHRLICHIA-CHAFFEENSIS [J].
CHEN, SM ;
DUMLER, JS ;
FENG, HM ;
WALKER, DH .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1994, 50 (01) :52-58
[9]   ISOLATION AND CHARACTERIZATION OF AN EHRLICHIA SP FROM A PATIENT DIAGNOSED WITH HUMAN EHRLICHIOSIS [J].
DAWSON, JE ;
ANDERSON, BE ;
FISHBEIN, DB ;
SANCHEZ, JL ;
GOLDSMITH, CS ;
WILSON, KH ;
DUNTLEY, CW .
JOURNAL OF CLINICAL MICROBIOLOGY, 1991, 29 (12) :2741-2745
[10]   HUMAN EHRLICHIOSIS - PROSPECTIVE ACTIVE SURVEILLANCE IN FEBRILE HOSPITALIZED-PATIENTS [J].
FISHBEIN, DB ;
KEMP, A ;
DAWSON, JE ;
GREENE, NR ;
REDUS, MA ;
FIELDS, DH .
JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (05) :803-809