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Life and death of the pancreatic β cells

被引：238
作者：
Bonner-Weir, S [1 ]
机构：
[1] Harvard Univ, Sch Med, Joslin Diabet Ctr, Boston, MA 02215 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S1043-2760(00)00305-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pancreatic beta cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia Throughout the lifetime of a mammal, low levels of beta -cell replication and apoptosis are balanced and result in a slowly increasing mass of beta cells. The emphasis in this review is on recent insights on the natural history of the beta cell in a normal pancreas: sources of renewal, survival and changes in differentiation.
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页码：375 / 378
页数：4
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