Impaired heart rate variability in euthymic bipolar patients

被引：63

作者：

Cohen, H ^{[1
]}

Kaplan, Z ^{[1
]}

Kotler, M ^{[1
]}

Mittelman, I ^{[1
]}

Osher, Y ^{[1
]}

Bersudsky, Y ^{[1
]}

机构：

[1] Ben Gurion Univ Negev, Fac Hlth Sci, Minist Hlth, Mental Hlth Ctr,Psychiat Res Unit, Beer Sheva, Israel

来源：

BIPOLAR DISORDERS | 2003年 / 5卷 / 02期

关键词：

autonomic nervous system; bipolar disorder; euthymic; heart rate variability; vagal tone;

D O I：

10.1034/j.1399-5618.2003.00027.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Power spectral analysis of heart rate variability (HRV) has recently been shown to be a reliable non-invasive test for quantitative assessment of the central sympathovagal interaction that modulates cardiovascular autonomic function. Methods: We studied 39 euthymic bipolar patients and 39 controls, matched for age and sex. A high-resolution electrocardiogram was obtained during complete rest. Spectral analysis of R-R intervals was performed by the fast Fourier transform algorithm. Results: Euthymic bipolar patients at rest are characterized by markedly low HRV, independent of specific drug treatments. Conclusion: While these results of autonomic stability in euthymic bipolar patients are counter-intuitive, the findings may be important in understanding pathophysiology of bipolar affective illness.

引用

页码：138 / 143

页数：6

共 37 条

[1] POWER SPECTRUM ANALYSIS OF HEART-RATE FLUCTUATION - A QUANTITATIVE PROBE OF BEAT-TO-BEAT CARDIOVASCULAR CONTROL [J].