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Standard antifungal therapy in neutropenic patients

被引：9
作者：
Aoun, M
机构：
[1] Inst Jules Bordet, Dept Malad Infect, B-1000 Brussels, Belgium
[2] Inst Jules Bordet, Microbiol Lab, B-1000 Brussels, Belgium
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2000年 / 16卷 / 02期
关键词：
fungal infections; prolonged neutropenia; amphotericin B;
D O I：
10.1016/S0924-8579(00)00220-X
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Fungal infections are life-threatening complications in patients with prolonged neutropenia. Amphotericin B, which is fungicidal and has a broad spectrum of antifungal activity, remains the current gold standard agent. However, because of its low therapeutic index, new lipid formulations of amphotericin B have been developed with better tolerance and less toxicity. The use of 5-fluorocytosine is waning because of the medullar toxicity of this agent. Fluconazole and itraconazole are both fungistatic and are more convenient for the treatment of fungal infections in haemodynamically stable patients. (C) 2000 Elsevier Science B.V. and International Society of Chemotherapy. All rights reserved.
引用
收藏
页码：143 / 145
页数：3
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